Aryl hydrocarbon receptor mediates laminar fluid shear stress-induced CYP1A1 activation and cell cycle arrest in vascular endothelial cells | Zendy

Zhihua Han | Zendy; Yoshikazu Miwa | Zendy; Hiyo Obikane | Zendy; Masako Mitsumata | Zendy; Fumi TakahashiYanaga | Zendy; Sachio Morimoto | Zendy; Toshiyuki Sasaguri | Zendy

Open Access

Aryl hydrocarbon receptor mediates laminar fluid shear stress-induced CYP1A1 activation and cell cycle arrest in vascular endothelial cells

Author(s) -

Zhihua Han,

Yoshikazu Miwa,

Hiyo Obikane,

Masako Mitsumata,

Fumi TakahashiYanaga,

Sachio Morimoto,

Toshiyuki Sasaguri

Publication year - 2007

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvm095

Subject(s) - aryl hydrocarbon receptor , microbiology and biotechnology , small interfering rna , cell cycle , transcription factor , chemistry , transcription (linguistics) , biology , apoptosis , transfection , biochemistry , gene , linguistics , philosophy

We investigated the mechanisms of shear stress (SS)-induced activation of cytochrome P450 (CYP) 1A1 and cell cycle arrest with regard to the role of the aryl hydrocarbon receptor (AhR), since AhR mediates the expression of CYP1A1 induced by polycyclic aromatic hydrocarbons (PAHs) and is thought to be involved in the regulation of cell growth and differentiation.

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