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VEGF-C induced angiogenesis preferentially occurs at a distance from lymphangiogenesis
Author(s) -
Andrew V. Benest,
Steven J. Harper,
Seppo YläHerttuala,
Kari Alitalo,
David O. Bates
Publication year - 2007
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvm094
Subject(s) - lymphangiogenesis , angiogenesis , lymphatic system , lymphatic endothelium , vascular endothelial growth factor c , lymphatic vessel , microbiology and biotechnology , biology , cancer research , vascular endothelial growth factor a , vascular endothelial growth factor , immunology , vegf receptors , metastasis , cancer , genetics
Vascular endothelial growth factor-C (VEGF-C) has been shown to stimulate both angiogenesis and lymphangiogenesis in some but not all models where VEGF-C is over-expressed. Our aim was to investigate the interaction between lymphangiogenesis and angiogenesis in adult tissues regulated by VEGF-C and identify evidence of polarized growth of lymphatics driven by specialized cells at the tip of the growing sprout.

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