Parathyroid hormone treatment after myocardial infarction promotes cardiac repair by enhanced neovascularization and cell survival | Zendy

MarcMichael Zaruba | Zendy; Bruno Hüber | Zendy; Stefan Brunner | Zendy; Elisabeth Deindl | Zendy; Robert David | Zendy; R Fischer | Zendy; Gerald Assmann | Zendy; Nadja Herbach | Zendy; Sebastian Grundmann | Zendy; Rüdiger Wanke | Zendy; Josef MuellerHoecker | Zendy; WolfgangMichael Franz | Zendy

Open Access

Parathyroid hormone treatment after myocardial infarction promotes cardiac repair by enhanced neovascularization and cell survival

Author(s) -

MarcMichael Zaruba,

Bruno Hüber,

Stefan Brunner,

Elisabeth Deindl,

Robert David,

R Fischer,

Gerald Assmann,

Nadja Herbach,

Sebastian Grundmann,

Rüdiger Wanke,

Josef MuellerHoecker,

WolfgangMichael Franz

Publication year - 2007

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvm080

Subject(s) - medicine , parathyroid hormone , neovascularization , stem cell , progenitor cell , myocardial infarction , endocrinology , cd34 , angiogenesis , vascular endothelial growth factor , cardiology , calcium , biology , vegf receptors , genetics

An ongoing concept is that stem cells have the potential to regenerate the injured myocardium. In addition to direct vasorelaxing effects on the vasculature, which are mediated by an increased cAMP production leading to a decreased calcium influx in smooth muscle cells, parathyroid hormone (PTH) was recently shown to facilitate stem cell mobilization. Therefore, we analysed in a murine model of experimental myocardial infarction (MI) the influence of PTH treatment on survival, functional parameters, stem cell migration, and expression of vascular endothelial growth factor A (VEGF-A).

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