Augmentation of late sodium current unmasks the proarrhythmic effects of amiodarone | Zendy

Lin Wu | Zendy; S. Rajamani | Zendy; John C. Shryock | Zendy; H. Li | Zendy; J N Ruskin | Zendy; Charles Antzelevitch | Zendy; Luiz Belardinelli | Zendy

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Augmentation of late sodium current unmasks the proarrhythmic effects of amiodarone

Author(s) -

Lin Wu,

S. Rajamani,

John C. Shryock,

H. Li,

J N Ruskin,

Charles Antzelevitch,

Luiz Belardinelli

Publication year - 2007

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvm069

Subject(s) - amiodarone , repolarization , medicine , herg , cardiology , pharmacology , sodium channel , chemistry , potassium channel , electrophysiology , sodium , atrial fibrillation , organic chemistry

Clinical use of amiodarone is associated with occasional development of torsade de pointes (TdP). However, preclinical models have failed to demonstrate the proarrhythmic potential of amiodarone. The objective of this study was to reveal and explain the pro- and anti-arrhythmic effects of acute exposure to amiodarone in an animal model.

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