Valproic acid interferes with antiviral treatment in human cytomegalovirus-infected endothelial cells | Zendy

Martin Michaelis | Zendy; T. A. T. Ha | Zendy; Hans Wilhelm Doerr | Zendy; Jindřich Činátl | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Valproic acid interferes with antiviral treatment in human cytomegalovirus-infected endothelial cells

Author(s) -

Martin Michaelis,

T. A. T. Ha,

Hans Wilhelm Doerr,

Jindřich Činátl

Publication year - 2007

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvm061

Subject(s) - human cytomegalovirus , foscarnet , ganciclovir , biology , virology , viral replication , pharmacology , virus

The endothelium represents a natural site of human cytomegalovirus (HCMV) infection involved in viral spreading and persistence. Moreover, HCMV infection of endothelial cells has been associated with different pathological conditions of the cardiovascular system. Here, the influence of the antiepileptic drug valproic acid (VPA) was investigated on HCMV replication in human umbilical vein endothelial cells alone or in combination with the antiviral drugs ganciclovir, cidofovir or foscarnet.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research