Alteration in flow (shear stress)-induced remodelling in rat resistance arteries with aging: improvement by a treatment with hydralazine | Zendy

Odile Dumont | Zendy; Frédéric Pinaud | Zendy; A.-L. Guihot | Zendy; Christophe Baufreton | Zendy; Laurent Loufrani | Zendy; Daniel Henrion | Zendy

Open Access

Alteration in flow (shear stress)-induced remodelling in rat resistance arteries with aging: improvement by a treatment with hydralazine

Author(s) -

Odile Dumont,

Frédéric Pinaud,

A.-L. Guihot,

Christophe Baufreton,

Laurent Loufrani,

Daniel Henrion

Publication year - 2007

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvm055

Subject(s) - hydralazine , vascular remodelling in the embryo , vasodilation , medicine , vascular resistance , blood flow , cardiology , arteriogenesis , hemodynamics , endocrinology , blood pressure , ischemia

The link between aging and vascular diseases remains unclear, especially in resistance arteries. As a decreased vasodilator capacity of the endothelium is usually described in aging, we hypothesized that arteriolar remodelling in response to a chronic increase in blood flow might be altered. In addition, we tested the capacity of a vasodilator treatment with hydralazine to restore remodelling, as we have previously shown that hydralazine has a potent effect on the process.

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