S-nitroso human serum albumin reduces ischaemia/reperfusion injury in the pig heart after unprotected warm ischaemia | Zendy

Seth Hallström | Zendy; Max Franz | Zendy; H. Gasser | Zendy; Martin Vodrazka | Zendy; Severin Semsroth | Zendy; Udo Losert | Zendy; Markus Haisjackl | Zendy; Bruno K. Podesser | Zendy; Tadeusz Maliñski | Zendy

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S-nitroso human serum albumin reduces ischaemia/reperfusion injury in the pig heart after unprotected warm ischaemia

Author(s) -

Seth Hallström,

Max Franz,

H. Gasser,

Martin Vodrazka,

Severin Semsroth,

Udo Losert,

Markus Haisjackl,

Bruno K. Podesser,

Tadeusz Maliñski

Publication year - 2007

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvm052

Subject(s) - ischemia , peroxynitrite , enos , medicine , reperfusion injury , nitric oxide , anesthesia , superoxide , endocrinology , cardiology , chemistry , nitric oxide synthase , biochemistry , enzyme

Uncoupled endothelial nitric oxide synthase (eNOS) is a major contributor to vascular reactive oxygen species generation in ischaemia/reperfusion (I/R) injury. Supplementation of NO by the novel NO donor S-nitroso human serum albumin (S-NO-HSA) may inhibit uncoupling of eNOS (feedback inhibition).

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