Changes in IK,ACh single-channel activity with atrial tachycardia remodelling in canine atrial cardiomyocytes | Zendy

Niels Voigt | Zendy; Ange Maguy | Zendy; Y.H. Yeh | Zendy; Xiaoyan Qi | Zendy; Ursula Ravens | Zendy; Dobromir Dobrev | Zendy; Stanley Nattel | Zendy

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Changes in IK,ACh single-channel activity with atrial tachycardia remodelling in canine atrial cardiomyocytes

Author(s) -

Niels Voigt,

Ange Maguy,

Y.H. Yeh,

Xiaoyan Qi,

Ursula Ravens,

Dobromir Dobrev,

Stanley Nattel

Publication year - 2007

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvm051

Subject(s) - cardiology , medicine , atrial tachycardia , tachycardia , atrial myocytes , atrial fibrillation , catheter ablation

Although atrial tachycardia (AT) remodelling promotes agonist-independent, constitutively active, acetylcholine-regulated K+-current (I K,ACh) that increases susceptibility to atrial fibrillation (AF), the underlying changes in I K,Ach channel function are unknown. This study aimed to establish how AT remodelling affects I K,ACh single-channel function.

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