Direct intramyocardial injection of mesenchymal stem cell sheet fragments improves cardiac functions after infarction | Zendy

ChungChi Wang | Zendy; ChunHung Chen | Zendy; Wei-Wen Lin | Zendy; ShiawMin Hwang | Zendy; Patrick C.H. Hsieh | Zendy; Po-Hong Lai | Zendy; YiChun Yeh | Zendy; Yen Chang | Zendy; HsingWen Sung | Zendy

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Direct intramyocardial injection of mesenchymal stem cell sheet fragments improves cardiac functions after infarction

Author(s) -

ChungChi Wang,

ChunHung Chen,

Wei-Wen Lin,

ShiawMin Hwang,

Patrick C.H. Hsieh,

Po-Hong Lai,

YiChun Yeh,

Yen Chang,

HsingWen Sung

Publication year - 2007

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvm046

Subject(s) - mesenchymal stem cell , transplantation , extracellular matrix , myocardial infarction , medicine , infarction , cell , extracellular , cardiology , saline , regeneration (biology) , pathology , chemistry , biology , microbiology and biotechnology , biochemistry

Cell transplantation is a promising approach for patients with myocardial infarction. However, following injection, retention of the transplanted cells in the injected area remains a central issue, which can be deleterious to cell transplantation therapy. We hypothesized that the use of cell sheet fragments, with the preservation of extracellular matrix (ECM), may significantly increase cell retention and thus improve cell therapy.

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