Low-density lipoproteins impair migration of human coronary vascular smooth muscle cells and induce changes in the proteomic profile of myosin light chain | Zendy

Teresa Padró | Zendy; Esther Peña | Zendy; Maisa García-Arguinzonis | Zendy; Vicenta LlorenteCortés | Zendy; Lina Badimón | Zendy

Open Access

Low-density lipoproteins impair migration of human coronary vascular smooth muscle cells and induce changes in the proteomic profile of myosin light chain

Author(s) -

Teresa Padró,

Esther Peña,

Maisa García-Arguinzonis,

Vicenta LlorenteCortés,

Lina Badimón

Publication year - 2007

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvm045

Subject(s) - myosin light chain kinase , myosin , vascular smooth muscle , smooth muscle , medicine , chemistry , immunoglobulin light chain , endocrinology , microbiology and biotechnology , biology , immunology , antibody

High-risk atheromatous plaques contain significant extra- and intracellular lipid deposits and very low smooth muscle cell numbers in the intima. However, the mechanisms inducing vessel wall remodelling and high-risk plaque composition are unknown. Low-density lipoproteins (LDLs) infiltrate the vessel wall and become retained and aggregated (agLDL) in the intima by binding to extracellular matrix proteoglycans. The cellular responses triggered by agLDL are not fully understood. This study was designed to investigate the effects of agLDL on vascular remodelling and repair, specifically studying human coronary vascular smooth muscle cell (VSMC) functions.

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