Regulation of swelling-activated Cl- current by angiotensin II signalling and NADPH oxidase in rabbit ventricle | Zendy

Zhengnan Ren | Zendy; F Raucci | Zendy; David M. Browe | Zendy; Clive M. Baumgarten | Zendy

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Regulation of swelling-activated Cl- current by angiotensin II signalling and NADPH oxidase in rabbit ventricle

Author(s) -

Zhengnan Ren,

F Raucci,

David M. Browe,

Clive M. Baumgarten

Publication year - 2007

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvm031

Subject(s) - angiotensin ii , chemistry , nadph oxidase , losartan , angiotensin ii receptor type 1 , medicine , endocrinology , reactive oxygen species , microbiology and biotechnology , receptor , biochemistry , biology

We assessed whether hypoosmotic swelling of cardiac myocytes activates volume-sensitive Cl(-) current (I Cl,swell) via the angiotensin II (AngII)-reactive oxygen species (ROS) signalling cascade. The AngII-ROS pathway previously was shown to elicit I(Cl,swell) upon mechanical stretch of beta(1D) integrin. Integrin stretch and osmotic swelling are, however, distinct stimuli. For example, blocking Src kinases stimulates swelling-induced but inhibits stretch-induced I Cl,swell.

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