Novel functional role of heat shock protein 90 in ATP-sensitive K+ channel-mediated hypoxic preconditioning | Zendy

Jundong Jiao | Zendy; Vivek Garg | Zendy; Binbin Yang | Zendy; Keli Hu | Zendy

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Novel functional role of heat shock protein 90 in ATP-sensitive K+ channel-mediated hypoxic preconditioning

Author(s) -

Jundong Jiao,

Vivek Garg,

Binbin Yang,

Keli Hu

Publication year - 2007

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvm028

Subject(s) - cardioprotection , ischemic preconditioning , kir6.2 , atp sensitive potassium channel , mechanism (biology) , potassium channel , medicine , chemistry , pharmacology , microbiology and biotechnology , ischemia , cardiology , biology , biochemistry , endocrinology , glibenclamide , protein subunit , diabetes mellitus , gene , philosophy , epistemology

ATP-sensitive K+ (K ATP) channels are implicated in the protective effect of ischaemic preconditioning (IPC). Kir6.2 has been shown to be involved in the cardioprotection of IPC. However, the mechanism by which Kir6.2-containing K ATP channels protect the heart is still largely unknown. The present study was designed to explore the potential mechanism involved in K ATP channel-mediated cardioprotection.

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