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ATP-sensitive K+ (K ATP) channels are implicated in the protective effect of ischaemic preconditioning (IPC). Kir6.2 has been shown to be involved in the cardioprotection of IPC. However, the mechanism by which Kir6.2-containing K ATP channels protect the heart is still largely unknown. The present study was designed to explore the potential mechanism involved in K ATP channel-mediated cardioprotection.

Novel functional role of heat shock protein 90 in ATP-sensitive K+ channel-mediated hypoxic preconditioning