Targeting of phospholamban by peroxynitrite decreases β-adrenergic stimulation in cardiomyocytes | Zendy

Mark J. Kohr | Zendy; Honglan Wang | Zendy; Debra G. Wheeler | Zendy; V. Murugesan | Zendy; Jay L. Zweíer | Zendy; Mark T. Ziolo | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Targeting of phospholamban by peroxynitrite decreases β-adrenergic stimulation in cardiomyocytes

Author(s) -

Mark J. Kohr,

Honglan Wang,

Debra G. Wheeler,

V. Murugesan,

Jay L. Zweíer,

Mark T. Ziolo

Publication year - 2007

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvm018

Subject(s) - phospholamban , peroxynitrite , medicine , myocyte , phosphorylation , endocrinology , sarcolemma , chemistry , phosphatase , adrenergic agonist , adrenergic , biology , biochemistry , superoxide , receptor , enzyme

Peroxynitrite production increases during the pathogenesis of numerous cardiac disorders (e.g. heart failure). However, limited studies have investigated the mechanism through which peroxynitrite exerts anti-adrenergic effects. Thus, the purpose of this study is to investigate the contribution of phospholamban (PLB), a critical excitation-contraction coupling protein, to the peroxynitrite-induced dysfunction.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research