Mitochondrial uncoupling protein 2 mediates temperature heterogeneity in atherosclerotic plaques | Zendy

Tim J.L. van de Parre | Zendy; Wim Martinet | Zendy; Stefan Verheye | Zendy; Mark Kockx | Zendy; Glenn Van Langenhove | Zendy; A. G. Herman | Zendy; Guido R.Y. De Meyer | Zendy

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Mitochondrial uncoupling protein 2 mediates temperature heterogeneity in atherosclerotic plaques

Author(s) -

Tim J.L. van de Parre,

Wim Martinet,

Stefan Verheye,

Mark Kockx,

Glenn Van Langenhove,

A. G. Herman,

Guido R.Y. De Meyer

Publication year - 2007

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvm003

Subject(s) - uncoupling protein , mitochondrion , microbiology and biotechnology , biology , chemistry , medicine , brown adipose tissue , endocrinology , adipose tissue

Rupture-prone atherosclerotic plaques show an elevated temperature, but a molecular explanation for this phenomenon is unknown. Here, we investigated whether mitochondrial uncoupling protein 2 (UCP2) could be involved because this protein is a macrophage homologue of thermogenin in brown fat tissue.

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