Initiation of ventricular arrhythmia in the acquired long QT syndrome | Zendy

Cherry Alexander | Zendy; Martin J. Bishop | Zendy; Rebecca J. Gilchrist | Zendy; Francis L. Burton | Zendy; Godfrey L. Smith | Zendy; Rachel C. Myles | Zendy

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Initiation of ventricular arrhythmia in the acquired long QT syndrome

Author(s) -

Cherry Alexander,

Martin J. Bishop,

Rebecca J. Gilchrist,

Francis L. Burton,

Godfrey L. Smith,

Rachel C. Myles

Publication year - 2022

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvac103

Subject(s) - torsades de pointes , medicine , long qt syndrome , ventricular tachycardia , nifedipine , cardiology , afterdepolarization , optical mapping , ventricular action potential , ventricular fibrillation , qt interval , electrophysiology , calcium , repolarization

Long QT syndrome (LQTS) carries a risk of life-threatening polymorphic ventricular tachycardia (Torsades de Pointes, TdP) and is a major cause of premature sudden cardiac death. TdP is induced by R-on-T premature ventricular complexes (PVCs), thought to be generated by cellular early-afterdepolarisations (EADs). However, EADs in tissue require cellular synchronisation, and their role in TdP induction remains unclear. We aimed to determine the mechanism of TdP induction in rabbit hearts with acquired LQTS (aLQTS).

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