PHACTR1modulates vascular compliance but not endothelial function: a translational study | Zendy

Alice Wood | Zendy; Alexios S. Antonopoulos | Zendy; Surawee Chuaiphichai | Zendy; Theodosios Kyriakou | Zendy; Rebeca Diaz | Zendy; Abtehale Al Hussaini | Zendy; Anna-Marie Marsh | Zendy; Manjit Sian | Zendy; Mitul Meisuria | Zendy; Gerry P McCann | Zendy; Victoria S Rashbrook | Zendy; Edward Drydale | Zendy; Sally Draycott | Zendy; Murray Polkinghorne | Zendy; Ioannis Akoumianakis | Zendy; Charalambos Antoniades | Zendy; Hugh Watkins | Zendy; Keith M. Chan | Zendy; David Adlam | Zendy; Gillian Douglas | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

PHACTR1modulates vascular compliance but not endothelial function: a translational study

Author(s) -

Alice Wood,

Alexios S. Antonopoulos,

Surawee Chuaiphichai,

Theodosios Kyriakou,

Rebeca Diaz,

Abtehale Al Hussaini,

Anna-Marie Marsh,

Manjit Sian,

Mitul Meisuria,

Gerry P McCann,

Victoria S Rashbrook,

Edward Drydale,

Sally Draycott,

Murray Polkinghorne,

Ioannis Akoumianakis,

Charalambos Antoniades,

Hugh Watkins,

Keith M. Chan,

David Adlam,

Gillian Douglas

Publication year - 2022

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvac092

Subject(s) - medicine , vascular disease , aorta , cardiology , pathology , biology

The non-coding locus at 6p24 located in Intron 3 of PHACTR1 has consistently been implicated as a risk allele in myocardial infarction and multiple other vascular diseases. Recent murine studies have identified a role for Phactr1 in the development of atherosclerosis. However, the role of PHACTR1 in vascular tone and in vivo vascular remodelling has yet to be established. The aim of this study was to investigate the role of PHACTR1 in vascular function.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research