The VWF/LRP4/αVβ3-axis represents a novel pathway regulating proliferation of human vascular smooth muscle cells | Zendy

Jérémy Lagrange | Zendy; Morel E. Worou | Zendy; JeanBaptiste Michel | Zendy; Alexandre Raoul | Zendy; Mélusine Didelot | Zendy; Vincent Muczynski | Zendy; Paulette Legendre | Zendy; François Plénat | Zendy; Guillaume Gauchotte | Zendy; Marc-Damien Lourenco-Rodrigues | Zendy; Olivier D. Christophe | Zendy; Peter J. Lenting | Zendy; Patrick Lacolley | Zendy; Cécile V. Denis | Zendy; Véronique Regnault | Zendy

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The VWF/LRP4/αVβ3-axis represents a novel pathway regulating proliferation of human vascular smooth muscle cells

Author(s) -

Jérémy Lagrange,

Morel E. Worou,

JeanBaptiste Michel,

Alexandre Raoul,

Mélusine Didelot,

Vincent Muczynski,

Paulette Legendre,

François Plénat,

Guillaume Gauchotte,

Marc-Damien Lourenco-Rodrigues,

Olivier D. Christophe,

Peter J. Lenting,

Patrick Lacolley,

Cécile V. Denis,

Véronique Regnault

Publication year - 2021

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvab042

Subject(s) - vascular smooth muscle , neointima , microbiology and biotechnology , intimal hyperplasia , von willebrand factor , receptor , chemistry , angiogenesis , proximity ligation assay , cell growth , biology , medicine , cancer research , endocrinology , immunology , platelet , biochemistry , smooth muscle , restenosis , stent

Von Willebrand factor (VWF) is a plasma glycoprotein involved in primary haemostasis, while also having additional roles beyond haemostasis namely in cancer, inflammation, angiogenesis, and potentially in vascular smooth muscle cell (VSMC) proliferation. Here, we addressed how VWF modulates VSMC proliferation and investigated the underlying molecular pathways and the in vivo pathophysiological relevance.

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