Interleukin-7 and interleukin-15 drive CD4+CD28null T lymphocyte expansion and function in patients with acute coronary syndrome | Zendy

Jessica Bullenkamp | Zendy; Veronica Mengoni | Zendy; Satdip Kaur | Zendy; Ismita Chhetri | Zendy; Paraskevi Dimou | Zendy; Zoë Astroulakis | Zendy; Juan Carlos Kaski | Zendy; Ingrid E. Dumitriu | Zendy

Open Access

Interleukin-7 and interleukin-15 drive CD4+CD28null T lymphocyte expansion and function in patients with acute coronary syndrome

Author(s) -

Jessica Bullenkamp,

Veronica Mengoni,

Satdip Kaur,

Ismita Chhetri,

Paraskevi Dimou,

Zoë Astroulakis,

Juan Carlos Kaski,

Ingrid E. Dumitriu

Publication year - 2020

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvaa202

Subject(s) - cd28 , cytotoxic t cell , interleukin 7 receptor , il 2 receptor , t cell , immunology , interleukin 21 , immune system , biology , in vitro , biochemistry

Inflammation has important roles in atherosclerosis. CD4+CD28null (CD28null) T cells are a specialized T lymphocyte subset that produce inflammatory cytokines and cytotoxic molecules. CD28null T cells expand preferentially in patients with acute coronary syndrome (ACS) rather than stable angina and are barely detectable in healthy subjects. Importantly, ACS patients with CD28null T-cell expansion have increased risk for recurrent acute coronary events and poor prognosis, compared to ACS patients in whom this cell subset does not expand. The mechanisms regulating CD28null T-cell expansion in ACS remain elusive. We therefore investigated the role of cytokines in CD28null T-cell expansion in ACS.

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