Ventricular fibrillation mechanism and global fibrillatory organization are determined by gap junction coupling and fibrosis pattern | Zendy

Balvinder S. Handa | Zendy; Xinyang Li | Zendy; Nicoleta Baxan | Zendy; Caroline H. Roney | Zendy; Anastasia Shchendrygina | Zendy; Catherine Mansfield | Zendy; Richard J. Jabbour | Zendy; David S. Pitcher | Zendy; Rasheda A. Chowdhury | Zendy; Nicholas S. Peters | Zendy; Fu Siong Ng | Zendy

Open Access

Ventricular fibrillation mechanism and global fibrillatory organization are determined by gap junction coupling and fibrosis pattern

Author(s) -

Balvinder S. Handa,

Xinyang Li,

Nicoleta Baxan,

Caroline H. Roney,

Anastasia Shchendrygina,

Catherine Mansfield,

Richard J. Jabbour,

David S. Pitcher,

Rasheda A. Chowdhury,

Nicholas S. Peters,

Fu Siong Ng

Publication year - 2020

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvaa141

Subject(s) - carbenoxolone , optical mapping , fibrosis , ventricular fibrillation , medicine , gap junction , cardiology , myocardial fibrosis , coupling (piping) , fibrillation , atrial fibrillation , endocrinology , chemistry , materials science , intracellular , biochemistry , metallurgy

Conflicting data exist supporting differing mechanisms for sustaining ventricular fibrillation (VF), ranging from disorganized multiple-wavelet activation to organized rotational activities (RAs). Abnormal gap junction (GJ) coupling and fibrosis are important in initiation and maintenance of VF. We investigated whether differing ventricular fibrosis patterns and the degree of GJ coupling affected the underlying VF mechanism.

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