Junctophilin-2 tethers T-tubules and recruits functional L-type calcium channels to lipid rafts in adult cardiomyocytes | Zendy

Claire Poulet | Zendy; Jose L. SanchezAlonso | Zendy; Pamela Swiatlowska | Zendy; Florence Mouy | Zendy; Carla Lucarelli | Zendy; Anita AlvarezLaviada | Zendy; Polina Gross | Zendy; Cesare M. Terracciano | Zendy; Steven R. Houser | Zendy; Julia Gorelik | Zendy

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Junctophilin-2 tethers T-tubules and recruits functional L-type calcium channels to lipid rafts in adult cardiomyocytes

Author(s) -

Claire Poulet,

Jose L. SanchezAlonso,

Pamela Swiatlowska,

Florence Mouy,

Carla Lucarelli,

Anita AlvarezLaviada,

Polina Gross,

Cesare M. Terracciano,

Steven R. Houser,

Julia Gorelik

Publication year - 2020

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvaa033

Subject(s) - ryanodine receptor , endoplasmic reticulum , microbiology and biotechnology , myocyte , voltage dependent calcium channel , biology , calcium , tubule , medicine , endocrinology , chemistry , biophysics , kidney

In cardiomyocytes, transverse tubules (T-tubules) associate with the sarcoplasmic reticulum (SR), forming junctional membrane complexes (JMCs) where L-type calcium channels (LTCCs) are juxtaposed to Ryanodine receptors (RyR). Junctophilin-2 (JPH2) supports the assembly of JMCs by tethering T-tubules to the SR membrane. T-tubule remodelling in cardiac diseases is associated with downregulation of JPH2 expression suggesting that JPH2 plays a crucial role in T-tubule stability. Furthermore, increasing evidence indicate that JPH2 might additionally act as a modulator of calcium signalling by directly regulating RyR and LTCCs. This study aimed at determining whether JPH2 overexpression restores normal T-tubule structure and LTCC function in cultured cardiomyocytes.

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