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Background  Gaps exist in our understanding of the clinical course of pouch-related disorders.    Methods  We evaluated baseline disease activity and longitudinal treatment patterns among patients with inflammatory conditions of the pouch.    Results  Among 468 patients with an ileal pouch-anal anastomosis (IPAA), 94 (20%) had acute pouchitis, 96 (21%) had chronic pouchitis, and 192 (41%) had Crohn disease of the pouch. Following an IPAA, 38% of patients were treated with a biologic and 11% underwent inflammatory bowel disease- or bowel-related surgery.    Conclusions  Treatment patterns after IPAA indicate that pouch-related disorders have a significant impact on individual patients and the healthcare system.

crohn's and colitis 360

Disease and Treatment Patterns Among Patients With Pouch-related Conditions in a Cohort of Large Tertiary Care Inflammatory Bowel Disease Centers in the United States