Open AccessDisease and Treatment Patterns Among Patients With Pouch-related Conditions in a Cohort of Large Tertiary Care Inflammatory Bowel Disease Centers in the United States
Author(s) -
Edward L. Barnes,
Laura H. Raffals,
Millie D. Long,
Gaurav Syal,
Maia Kayal,
Ashwin N. Ananthakrishnan,
Benjamin L. Cohen,
Joel Pekow,
Parakkal Deepak,
JeanFrédéric Colombel,
Hans Herfarth,
Robert S. Sandler
Publication year - 2020
Publication title -
crohn s and colitis 360
Language(s) - English
Resource type - Journals
ISSN - 2631-827X
DOI - 10.1093/crocol/otaa039
Subject(s) - pouchitis , pouch , medicine , inflammatory bowel disease , disease , gastroenterology , anastomosis , cohort , ulcerative colitis , tertiary care , crohn's disease , surgery
Background Gaps exist in our understanding of the clinical course of pouch-related disorders. Methods We evaluated baseline disease activity and longitudinal treatment patterns among patients with inflammatory conditions of the pouch. Results Among 468 patients with an ileal pouch-anal anastomosis (IPAA), 94 (20%) had acute pouchitis, 96 (21%) had chronic pouchitis, and 192 (41%) had Crohn disease of the pouch. Following an IPAA, 38% of patients were treated with a biologic and 11% underwent inflammatory bowel disease- or bowel-related surgery. Conclusions Treatment patterns after IPAA indicate that pouch-related disorders have a significant impact on individual patients and the healthcare system.
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