Open AccessEvolution and Dissemination of β-Lactamases Accelerated by Generations of β-Lactam Antibiotics
Author(s) -
Antone A. Medeiros
Publication year - 1997
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/clinids/24.supplement_1.s19
Subject(s) - medicine , antibiotics , beta lactam , microbiology and biotechnology , lactam , biology , stereochemistry , chemistry
beta-Lactamases are the principal mechanism of bacterial resistance to beta-lactam antibiotics. In recent years the number and variety of new beta-lactamases detected has risen at an alarming rate, apparently in response to the clinical use of novel classes of beta-lactam antibiotics. This paper reviews the structure and evolution of beta-lactamases in an attempt to understand the pressures that have contributed to their emergence.
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