Open AccessSevere, Protracted Intestinal Cryptosporidiosis Associated with Interferon Deficiency: Pediatric Case Report
Author(s) -
María Ángeles Gómez-Morales,
Clara Maria Ausiello,
Alfredo Guarino,
Francesca Urbani,
Maria Immacolata Spagnuolo,
Claudio Pignata,
Edoardo Pozio
Publication year - 1996
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/clinids/22.5.848
Subject(s) - cryptosporidium parvum , peripheral blood mononuclear cell , medicine , diarrhea , immune system , immunology , interferon gamma , cryptosporidium , immunopathology , interferon , cellular immunity , interleukin 2 , virology , feces , biology , microbiology and biotechnology , in vitro , biochemistry
We describe a human immunodeficiency virus-negative infant with chronic intractable diarrhea due to Cryptosporidium parvum; he had a history of significant weight loss since the second week of life. A preliminary study of his immune function was negative for primary immunodeficiency. To further study his immune function, proliferation of peripheral blood mononuclear cells (PBMCs) was elicited by crude antigenic extract from C. parvum oocysts (CCE). Supernatants of CCE-stimulated PBMCs contained interleukin 10 but not interferon gamma (IFN-gamma), while PBMCs from a control (a 2-year-old immunocompetent infant who had recovered from cryptosporidiosis) showed a strong response to IFN-gamma when stimulated with CCE. These results stress the role of IFN-gamma in recovery from cryptosporidiosis.
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