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Failure of Postexposure Treatment of Rabies in Children
Author(s) -
Henry Wilde,
Siriwan Sirikawin,
A Sabcharoen,
Darika Kingnate,
T. Tantawichien,
P. A. L. Harischandra,
Narongsak Chaiyabutr,
D. G. H. de Silva,
Luís Fernando,
Jayantha Liyanage,
Visith Sitprija
Publication year - 1996
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/clinids/22.2.228
Subject(s) - rabies , medicine , immune system , globulin , infiltration (hvac) , gamma globulin , rabies virus , antibody , immunology , surgery , virology , physics , thermodynamics
Five failures of postexposure treatment of rabies in small children with multiple severe bites on the face and head are discussed. All had received rabies immune globulin and a potent tissue-culture vaccine. However, not all wounds had been infiltrated with immune globulin. Surgical closure prior to wound injection with immune globulin was performed in three cases. Another patient had wounds sutured after an intramuscular injection of immune globulin, without wound infiltration.

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