Improved Sensitivity of Capillary Electrophoresis for Detection of Bisalbuminemia

We wish to report our findings on bisalbuminemia detected by capillary electrophoresis. Bisalbuminemia is an abnormality characterized by a double band of albumin seen on electrophoresis. This anomaly can be either inherited or acquired. The inherited familial bisalbuminemia is a rare abnormality with no pathologic or therapeutic consequences, being of interest only for human genetics or anthropology (1). By contrast, the detection of an acquired and transitory bisalbuminemia may point to an overdose of antibiotics or the presence of ascites or a pancreatic pseudocyst (2)(3).Since the introduction of the Paragon 2000TM capillary zone electrophoresis (CZE) system (Beckman Instruments) in our laboratory, we have noted an increased frequency of identified cases of bisalbuminemia. The electrophoretic separation …