Propofol-associated Rhabdomyolysis with Cardiac Involvement in Adults: Chemical and Anatomic Findings | Zendy

Edward B. Stelow | Zendy; Vandita Johari | Zendy; Stephen A. Smith | Zendy; John T. Crosson | Zendy; Fred S. Apple | Zendy

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Propofol-associated Rhabdomyolysis with Cardiac Involvement in Adults: Chemical and Anatomic Findings

Author(s) -

Edward B. Stelow,

Vandita Johari,

Stephen A. Smith,

John T. Crosson,

Fred S. Apple

Publication year - 2000

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1093/clinchem/46.4.577

Subject(s) - rhabdomyolysis , creatine kinase , medicine , propofol , sedative , troponin , skeletal muscle , cardiac muscle , anesthesia , autopsy , troponin i , cardiology , myocardial infarction

Propofol, a central-acting sedative agent, has been implicated in the development of rhabdomyolysis in children. We describe two adults who developed rhabdomyolysis after receiving high rates of propofol infusion. Rhabdomyolysis of both skeletal and cardiac muscle was suggested in both patients by marked increases of creatine kinase (>170 000 U/L) and cardiac troponin I (11 and 46 microg/L in patients one and two, respectively). Creatine kinase and cardiac troponin I values were highly correlated in each patent (r = 0.786 and 0.988 in patients one and two, respectively). Autopsy of one patient confirmed the diagnosis of skeletal and cardiac rhabdomyolysis.

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