Survey of Total Error of Precipitation and Homogeneous HDL-Cholesterol Methods and Simultaneous Evaluation of Lyophilized Saccharose-containing Candidate Reference Materials for HDL-Cholesterol | Zendy

Christa M. Cobbaert | Zendy; Paul Mulder | Zendy; H Baadenhuijsen | Zendy; L. Zwang | Zendy; Cas Weykamp | Zendy; Pierre N.M. Demacker | Zendy

Open Access

Survey of Total Error of Precipitation and Homogeneous HDL-Cholesterol Methods and Simultaneous Evaluation of Lyophilized Saccharose-containing Candidate Reference Materials for HDL-Cholesterol

Author(s) -

Christa M. Cobbaert,

Paul Mulder,

H Baadenhuijsen,

L. Zwang,

Cas Weykamp,

Pierre N.M. Demacker

Publication year - 1999

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1093/clinchem/45.3.360

Subject(s) - homogeneous , cholesterol , national cholesterol education program , ldl cholesterol , total cholesterol , chromatography , chemistry , medicine , mathematics , biochemistry , combinatorics , metabolic syndrome , obesity

BACKGROUNDStandardization of HDL-cholesterol is needed for risk assessment. We assessed for the first time the accuracy of HDL-cholesterol testing in The Netherlands and evaluated 11 candidate reference materials (CRMs).METHODSThe total error (TE) of HDL-cholesterol measurements was assessed in native human sera by 25 Dutch clinical chemistry laboratories. Concomitantly, the suitability of lyophilized, saccharose-containing CRMs (n = 11) for HDL-cholesterol was evaluated.RESULTSIn the precipitation method group, which included 25 laboratories and four methods, the mean (minimum-maximum) TE was 11.5% (2.7-25.2%), signifying that 18 of 25 laboratories satisfied the TE goal of

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