Open AccessPSA Concentrations in Seminal Plasma
Author(s) -
Tang J. Wang,
Harry G. Rittenhouse,
Robert L. Wolfert,
Charles M. Lynne,
Nancy L. Brackett
Publication year - 1998
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1093/clinchem/44.4.895a
Subject(s) - serine protease , prostate specific antigen , prostate cancer , fibronectin , prostate , laminin , serine , antigen , chemistry , medicine , endocrinology , protease , biology , cancer , biochemistry , extracellular matrix , immunology , enzyme
Prostate specific antigen (PSA) is an important tumor marker for the detection and monitoring of prostate cancer. PSA is secreted by the prostatic epithelial cells into the lumen of the prostate duct during the formation of seminal plasma. PSA is a 30 kDa serine protease that cleaves biological substrates in seminal fluid, including seminogelin I, seminogelin II, and fibronectin, into small peptides, resulting in increased sperm motility (1)(2)(3)(4). PSA has also been shown to cleave other biological substrates, including insulin-like growth factor-binding protein-3 and laminin, indicating …
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