Open AccessClinical evaluation of the Byk LIA-mat CA125 II assay: discussion of a reference value
Author(s) -
Johannes M.G. Bonfrèr,
Catharina M. Korse,
Rob A. Verstraeten,
Gerard J. van Kamp,
Guus Hart,
Peter Kenemans
Publication year - 1997
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1093/clinchem/43.3.491
Subject(s) - gynecology , medicine , percentile , gastroenterology , epithelial ovarian cancer , cancer , ovarian cancer , statistics , mathematics
The Byk LIA-mat CA125 II assay was compared with the Centocor IRMA CA125 II. Serum samples studied (n = 1012) were obtained from 652 apparently healthy females, 61 pregnant women, and 299 patients with benign and malignant gynecological tumors. The CA125 II assay value at the 95th percentile of the total healthy group was 29 kU/L for the LIA-mat and 32 kU/L for the Centocor assay. For the LIA-mat assay the 95th percentile was 31 kU/L (Centocor 36 kU/L) for the group < 45 years and 21 kU/L (Centocor 25 kU/L) for women > 55 years of age. By using ROC curves we found the optimal pretreatment Byk LIA-mat CA125 II value differentiating between benign and malignant ovarian tumors to be 95 kU/L. Pretreatment CA125 values > 1000 kU/L were detected in serum samples of patients with advanced epithelial ovarian cancer.
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