Dramatic increase in parathyroid hormone and hypocalcaemia after denosumab in a kidney transplanted patient | Zendy

JoséVicente Torregrosa | Zendy

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Dramatic increase in parathyroid hormone and hypocalcaemia after denosumab in a kidney transplanted patient

Author(s) -

JoséVicente Torregrosa

Publication year - 2012

Publication title -

clinical kidney journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.033

H-Index - 40

eISSN - 2048-8513

pISSN - 2048-8505

DOI - 10.1093/ckj/sfs158

Subject(s) - hypocalcaemia , medicine , denosumab , hypercalcaemia , parathyroid hormone , vitamin d and neurology , endocrinology , urology , calcium , osteoporosis

de Beus et al. report a case of a patient with immobilization-related hypercalcaemia and advanced renal insufficiency that did not respond to bisphosphonates, and after a single dose of denosumab (60 mg), a rapid and sustained decrease of the serum calcium concentration was observed with a transient hypocalcaemia which needed the introduction of oral calcium and active vitamin D to correct it [1]. Simultaneously with hypocalcaemia, the patient showed a moderate increase in parathyroid hormone (PTH) levels in blood.

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