Rescue of kidney function in a toddler with anti-GBM nephritis | Zendy

Anna Bjerre | Zendy; Kolbjørn Högåsen | Zendy; James C. Grotta | Zendy; Helge Scott | Zendy; Trine Tangeraas | Zendy; Christina Dörje | Zendy

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Rescue of kidney function in a toddler with anti-GBM nephritis

Author(s) -

Anna Bjerre,

Kolbjørn Högåsen,

James C. Grotta,

Helge Scott,

Trine Tangeraas,

Christina Dörje

Publication year - 2012

Publication title -

clinical kidney journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.033

H-Index - 40

eISSN - 2048-8513

pISSN - 2048-8505

DOI - 10.1093/ckj/sfs146

Subject(s) - medicine , rapidly progressive glomerulonephritis , renal function , nephritis , cyclophosphamide , creatinine , toddler , methylprednisolone , kidney , glomerular basement membrane , gastroenterology , pathology , urology , glomerulonephritis , chemotherapy , psychology , developmental psychology

Anti-glomerular basement membrane (anti-GBM) nephritis is rare in childhood with few published cases. We report a 19-month-old boy with rapidly progressive glomerulonephritis (RPGN) due to anti-GBM nephritis. Treatment was started under 2 weeks after presentation and included plasma exchange, intravenous high-dose methylprednisolone, intravenous cyclophosphamide and mycophenolate as mainstay medication. The treatment was rapidly effective with immediate decrease in anti-GBM titres and plasma creatinine. Three years after presentation, the boy has normal kidney function, blood pressure and no residual disease. The successful outcome was likely due to the rapid recognition of the anti-GBM antibodies as the cause of RPGN and aggressive primary treatment.

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