Open AccessHypoxia during maintenance hemodialysis—the critical role of pH
Author(s) -
Scott McGuire,
Nithya Krishnan,
Abdul R Malik,
Alex Waddell,
Sophie L Russell,
Francesca Denton,
Stuart Ennis,
E. W. Horton,
Djordje G. Jakovljevic,
G. McGregor
Publication year - 2022
Publication title -
clinical kidney journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 40
eISSN - 2048-8513
pISSN - 2048-8505
DOI - 10.1093/ckj/sfac191
Subject(s) - hemodialysis , medicine , hypoxia (environmental) , hemodynamics , oxygen–haemoglobin dissociation curve , cardiology , bicarbonate , hemoglobin , oxygen , chemistry , organic chemistry
The impact and management of subclinical hypoxia during hemodialysis is a significant medical challenge. As key determinants of O 2 availability and delivery, proposed mechanisms contributing to hypoxia include ischemia, alkalemia and pulmonary leukocyte sequestration. However, no study has comprehensively investigated and compared these interrelated mechanisms throughout a typical hemodialysis treatment week. This study aimed to comprehensively assess the physiological mechanisms that contribute to hypoxia during hemodialysis.