Open AccessOral vs Intravenous Antibiotics for Patients With Klebsiella pneumoniae Liver Abscess: A Randomized, Controlled Noninferiority Study
Author(s) -
James S. Molton,
Mónica Chan,
Shirin Kalimuddin,
Jolene Oon,
Barnaby Edward Young,
Jenny G. Low,
Brenda Mae Alferez Salada,
Tau Hong Lee,
Limin Wijaya,
Dale Fisher,
Ezlyn Izharuddin,
Tse Hsien Koh,
Jeanette Teo,
Prabha Krishnan,
Bien Peng Tan,
Winston Woon,
Ying Ding,
Yuan Wei,
Rachel Phillips,
Rajesh Babu Moorakonda,
Kah Hung Yuen,
Boon Piang Cher,
Joanne Yoong,
David Chien Lye,
Sophia Archuleta
Publication year - 2019
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/ciz881
Subject(s) - medicine , antibiotics , clinical endpoint , randomized controlled trial , liver abscess , pyogenic liver abscess , surgery , adverse effect , abscess , population , ciprofloxacin , confidence interval , ceftriaxone , environmental health , microbiology and biotechnology , biology
Klebsiella pneumoniae liver abscess (KLA) is emerging worldwide due to hypermucoviscous strains with a propensity for metastatic infection. Treatment includes drainage and prolonged intravenous antibiotics. We aimed to determine whether oral antibiotics were noninferior to continued intravenous antibiotics for KLA.
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