Methylation in Predicting Progression of Untreated High-grade Cervical Intraepithelial Neoplasia | Zendy

Karolina Louvanto | Zendy; Karoliina Aro | Zendy; Belinda Nedjai | Zendy; Ralf Bützow | Zendy; Maija Jakobsson | Zendy; Ilkka Kalliala | Zendy; Joakim Dillner | Zendy; Pekka Nieminen | Zendy; Attila T. Lörincz | Zendy

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Methylation in Predicting Progression of Untreated High-grade Cervical Intraepithelial Neoplasia

Author(s) -

Karolina Louvanto,

Karoliina Aro,

Belinda Nedjai,

Ralf Bützow,

Maija Jakobsson,

Ilkka Kalliala,

Joakim Dillner,

Pekka Nieminen,

Attila T. Lörincz

Publication year - 2019

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciz677

Subject(s) - medicine , cervical intraepithelial neoplasia , methylation , dna methylation , oncology , gynecology , pregnancy , obstetrics , cervical cancer , cancer , genetics , dna , gene , biology , gene expression

There is no prognostic test to ascertain whether cervical intraepithelial neoplasias (CINs) regress or progress. The majority of CINs regress in young women, and treatments increase the risk of adverse pregnancy outcomes. We investigated the ability of a DNA methylation panel (the S5 classifier) to discriminate between outcomes among young women with untreated CIN grade 2 (CIN2).

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