Immune Reconstitution Inflammatory Syndrome as a Posttransplantation Complication in Primary Immunodeficiency With Disseminated Mycobacterium avium | Zendy

Maura Manion | Zendy; Dimana Dimitrova | Zendy; Luxin Pei | Zendy; Juan GeaBanacloche | Zendy; Adrian M. Zelazny | Zendy; Andrea Lisco | Zendy; Christa S. Zerbe | Zendy; Alexandra F. Freeman | Zendy; Steven M. Holland | Zendy; Christopher G. Kanakry | Zendy; Jennifer A. Kanakry | Zendy; Irini Sereti | Zendy

Open Access

Immune Reconstitution Inflammatory Syndrome as a Posttransplantation Complication in Primary Immunodeficiency With Disseminated Mycobacterium avium

Author(s) -

Maura Manion,

Dimana Dimitrova,

Luxin Pei,

Juan GeaBanacloche,

Adrian M. Zelazny,

Andrea Lisco,

Christa S. Zerbe,

Alexandra F. Freeman,

Steven M. Holland,

Christopher G. Kanakry,

Jennifer A. Kanakry,

Irini Sereti

Publication year - 2019

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciz507

Subject(s) - immune reconstitution inflammatory syndrome , immunology , primary immunodeficiency , immune system , medicine , hematopoietic stem cell transplantation , pathogen , immunodeficiency , concomitant , transplantation , virus , viral load , antiretroviral therapy

Patients with primary immunodeficiencies undergoing allogeneic hematopoietic cell transplantation (HCT) for difficult-to-control infections can experience immune reconstitution inflammatory syndrome (IRIS) following engraftment. In 3 patients with post-HCT IRIS related to mycobacterial infection, in vitro data demonstrate the emergence of pathogen-specific immune responses and a concomitant rise in plasma inflammatory markers.

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