Fecal Immunoglobulin A Against a Sporozoite Antigen at 12 Months Is Associated With Delayed Time to Subsequent Cryptosporidiosis in Urban Bangladesh: A Prospective Cohort Study | Zendy

Kevin L. Steiner | Zendy; Mamun Kabir | Zendy; Jeffrey W. Priest | Zendy; Biplob Hossain | Zendy; Carol A. Gilchrist | Zendy; Heather Cook | Zendy; Z. Jennie | Zendy; Poonum Korpe | Zendy; Tahmeed Ahmed | Zendy; A. S. G. Faruque | Zendy; Rashidul Haque | Zendy; William A. Petri | Zendy

Open Access

Fecal Immunoglobulin A Against a Sporozoite Antigen at 12 Months Is Associated With Delayed Time to Subsequent Cryptosporidiosis in Urban Bangladesh: A Prospective Cohort Study

Author(s) -

Kevin L. Steiner,

Mamun Kabir,

Jeffrey W. Priest,

Biplob Hossain,

Carol A. Gilchrist,

Heather Cook,

Z. Jennie,

Poonum Korpe,

Tahmeed Ahmed,

A. S. G. Faruque,

Rashidul Haque,

William A. Petri

Publication year - 2019

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciz430

Subject(s) - cryptosporidium , medicine , feces , immunology , prospective cohort study , antibody , immunoglobulin a , immunoglobulin g , antigen , cohort , cohort study , immunity , microbiology and biotechnology , immune system , biology

In this prospective cohort study of Bangladeshi children, greater fecal immunoglobulin A, but not plasma immunoglobulin G, directed against the Cryptosporidium sporozoite-expressed antigen Cp23 at 12 months of age was associated with delayed time to subsequent cryptosporidiosis. This finding suggests a protective role for mucosal antibody-mediated immunity in naturally exposed children.

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