The Impact of Varicella Vaccination on the Incidence of Varicella and Herpes Zoster in the United States: Updated Evidence From Observational Databases, 1991–2016 | Zendy

Lara J. Wolfson | Zendy; Vincent Daniels | Zendy; Alexandra Altland | Zendy; Wya Black | Zendy; Vincy Huang | Zendy; Wanmei Ou | Zendy

Open Access

The Impact of Varicella Vaccination on the Incidence of Varicella and Herpes Zoster in the United States: Updated Evidence From Observational Databases, 1991–2016

Author(s) -

Lara J. Wolfson,

Vincent Daniels,

Alexandra Altland,

Wya Black,

Vincy Huang,

Wanmei Ou

Publication year - 2019

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciz305

Subject(s) - medicine , observational study , incidence (geometry) , vaccination , chickenpox vaccine , pediatrics , varicella zoster virus , varicella vaccine , virology , immunization , immunology , virus , antibody , physics , optics

Universal childhood vaccination against varicella began in the United States as a 1-dose schedule in 1996, changing to a 2-dose schedule in 2006. The exogenous boosting hypothesis, which postulates that reexposure to circulating wild-type varicella delays the onset of herpes zoster, predicts a transient increase in the incidence of herpes zoster, peaking in adults 15-35 years after the start of varicella vaccination.

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