Open AccessDynamic Prediction of Death in Patients With Tuberculous Meningitis Using Time-updated Glasgow Coma Scale and Plasma Sodium Measurements
Author(s) -
Lê Thị Phương Thảo,
Marcel Wolbers,
A Dorothee Heemskerk,
Nguyen Thi Hoang,
Đặng Thị Minh Hà,
Tran Thi Hong Chau,
Nguyen Hoan Phu,
Nguyễn Văn Vĩnh Châu,
Maxine Caws,
Nguyễn Hữu Lân,
Do Dang Anh Thu,
Nguyễn Thụy Thương Thương,
Jeremy Day,
M. Estée Török,
Nguyen Duc Bang,
Guy Thwaites,
Ronald B. Geskus
Publication year - 2019
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/ciz262
Subject(s) - glasgow coma scale , medicine , tuberculous meningitis , receiver operating characteristic , human immunodeficiency virus (hiv) , area under the curve , glasgow outcome scale , meningitis , surgery , immunology
Pretreatment predictors of death from tuberculous meningitis (TBM) are well established, but whether outcome can be predicted more accurately after the start of treatment by updated clinical variables is unknown. Hence, we developed and validated models that dynamically predict mortality using time-updated Glasgow Coma Scale (GCS) and plasma sodium measurements, together with patient baseline characteristics.
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