Addition of Flucytosine to Fluconazole for the Treatment of Cryptococcal Meningitis in Africa: A Multicountry Cost-effectiveness Analysis | Zendy

Tinevimbo Shiri | Zendy; Angela Loyse | Zendy; Lawrence Mwenge | Zendy; Tao Chen | Zendy; Shabir Lakhi | Zendy; Duncan Chanda | Zendy; Peter Mwaba | Zendy; Síle F. Molloy | Zendy; Robert S. Heyderman | Zendy; Cecilia Kanyama | Zendy; Mina C. Hosseinipour | Zendy; Charles Kouanfack | Zendy; Elvis Temfack | Zendy; Sayoki Mfinanga | Zendy; Sokoine Kivuyo | Zendy; Adrienne K Chan | Zendy; Joseph N Jarvis | Zendy; Olivier Lortholary | Zendy; Shabbar Jaffar | Zendy; Louis Niessen | Zendy; Thomas S. Harrison | Zendy

Open Access

Addition of Flucytosine to Fluconazole for the Treatment of Cryptococcal Meningitis in Africa: A Multicountry Cost-effectiveness Analysis

Author(s) -

Tinevimbo Shiri,

Angela Loyse,

Lawrence Mwenge,

Tao Chen,

Shabir Lakhi,

Duncan Chanda,

Peter Mwaba,

Síle F. Molloy,

Robert S. Heyderman,

Cecilia Kanyama,

Mina C. Hosseinipour,

Charles Kouanfack,

Elvis Temfack,

Sayoki Mfinanga,

Sokoine Kivuyo,

Adrienne K Chan,

Joseph N Jarvis,

Olivier Lortholary,

Shabbar Jaffar,

Louis Niessen,

Thomas S. Harrison

Publication year - 2019

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciz163

Subject(s) - fluconazole , flucytosine , cryptococcal meningitis , medicine , meningitis , antifungal , virology , pediatrics , human immunodeficiency virus (hiv) , dermatology , viral disease

Mortality from cryptococcal meningitis remains very high in Africa. In the Advancing Cryptococcal Meningitis Treatment for Africa (ACTA) trial, 2 weeks of fluconazole (FLU) plus flucytosine (5FC) was as effective and less costly than 2 weeks of amphotericin-based regimens. However, many African settings treat with FLU monotherapy, and the cost-effectiveness of adding 5FC to FLU is uncertain.

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