Transmission-blocking Effects of Primaquine and Methylene Blue Suggest Plasmodium falciparum Gametocyte Sterilization Rather Than Effects on Sex Ratio | Zendy

John Bradley | Zendy; Harouna M. Soumare | Zendy; Almahamoudou Mahamar | Zendy; Halimatou Diawara | Zendy; Michelle E. Roh | Zendy; Michael J. Delves | Zendy; Chris Drakeley | Zendy; Thomas S. Churcher | Zendy; Alassane Dicko | Zendy; Roly Gosling | Zendy; Teun Bousema | Zendy

Open Access

Transmission-blocking Effects of Primaquine and Methylene Blue Suggest Plasmodium falciparum Gametocyte Sterilization Rather Than Effects on Sex Ratio

Author(s) -

John Bradley,

Harouna M. Soumare,

Almahamoudou Mahamar,

Halimatou Diawara,

Michelle E. Roh,

Michael J. Delves,

Chris Drakeley,

Thomas S. Churcher,

Alassane Dicko,

Roly Gosling,

Teun Bousema

Publication year - 2019

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciz134

Subject(s) - gametocyte , primaquine , sex ratio , methylene blue , malaria , plasmodium falciparum , virology , biology , toxicology , medicine , immunology , chloroquine , biochemistry , environmental health , population , photocatalysis , catalysis

Gametocyte density and sex ratio can predict the proportion of mosquitoes that will become infected after feeding on blood of patients receiving nongametocytocidal drugs. Because primaquine and methylene blue sterilize gametocytes before affecting their density and sex ratio, mosquito feeding experiments are required to demonstrate their early transmission-blocking effects.

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