Model-Based Meta-analysis of Rifampicin Exposure and Mortality in Indonesian Tuberculous Meningitis Trials | Zendy

Elin M. Svensson | Zendy; Sofiati Dian | Zendy; Lindsey te Brake | Zendy; Ahmad Rizal Ganiem | Zendy; Vycke Yunivita | Zendy; Arjan van Laarhoven | Zendy; Reinout van Crevel | Zendy; Rovina Ruslami | Zendy; Rob E. Aarnoutse | Zendy

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Model-Based Meta-analysis of Rifampicin Exposure and Mortality in Indonesian Tuberculous Meningitis Trials

Author(s) -

Elin M. Svensson,

Sofiati Dian,

Lindsey te Brake,

Ahmad Rizal Ganiem,

Vycke Yunivita,

Arjan van Laarhoven,

Reinout van Crevel,

Rovina Ruslami,

Rob E. Aarnoutse

Publication year - 2019

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciz1071

Subject(s) - medicine , rifampicin , confidence interval , pharmacokinetics , tuberculous meningitis , hazard ratio , pharmacology , gastroenterology , meningitis , surgery , tuberculosis , pathology

Intensified antimicrobial treatment with higher rifampicin doses may improve outcome of tuberculous meningitis, but the desirable exposure and necessary dose are unknown. Our objective was to characterize the relationship between rifampicin exposures and mortality in order to identify optimal dosing for tuberculous meningitis.

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