Open AccessStreptococcus pyogenes pbp2x Mutation Confers Reduced Susceptibility to β-Lactam Antibiotics
Author(s) -
Kirsten Vannice,
Jessica N. Ricaldi,
Srinivas Nanduri,
Ferric C. Fang,
John B. Lynch,
Chloe BrysonCahn,
Theodore Wright,
Jeff Duchin,
Meagan Kay,
Sopio Chochua,
Chris Van Beneden,
Bernard Beall
Publication year - 2019
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/ciz1000
Subject(s) - cefotaxime , ampicillin , streptococcus pyogenes , microbiology and biotechnology , amoxicillin , antibiotics , lactam , minimum inhibitory concentration , medicine , penicillin , missense mutation , antibacterial agent , streptococcus , biology , mutation , bacteria , genetics , chemistry , staphylococcus aureus , gene , stereochemistry
Two near-identical clinical Streptococcus pyogenes isolates of emm subtype emm43.4 with a pbp2x missense mutation (T553K) were detected. Minimum inhibitory concentrations (MICs) for ampicillin and amoxicillin were 8-fold higher, and the MIC for cefotaxime was 3-fold higher than for near-isogenic control isolates, consistent with a first step in developing β-lactam resistance.
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