Children With Cystic Fibrosis Are Infected With Multiple Subpopulations of Mycobacterium abscessus With Different Antimicrobial Resistance Profiles | Zendy

Liam P. Shaw | Zendy; Ronan Doyle | Zendy; Ema Kavaliūnaitė | Zendy; Helen Spencer | Zendy; François Balloux | Zendy; Garth Dixon | Zendy; Kathryn Harris | Zendy

Open Access

Children With Cystic Fibrosis Are Infected With Multiple Subpopulations of Mycobacterium abscessus With Different Antimicrobial Resistance Profiles

Author(s) -

Liam P. Shaw,

Ronan Doyle,

Ema Kavaliūnaitė,

Helen Spencer,

François Balloux,

Garth Dixon,

Kathryn Harris

Publication year - 2019

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciz069

Subject(s) - mycobacterium abscessus , cystic fibrosis , sputum , medicine , antibiotic resistance , antibiotics , lung transplantation , sputum culture , immunology , lung , microbiology and biotechnology , mycobacterium , pathology , biology , tuberculosis

Children with cystic fibrosis (CF) can develop life-threatening infections of Mycobacterium abscessus. These present a significant clinical challenge, particularly when the strains involved are resistant to antibiotics. Recent evidence of within-patient subclones of M. abscessus in adults with CF suggests the possibility that within-patient diversity may be relevant for the treatment of pediatric CF patients.

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