Diagnostic Accuracy of Early Secretory Antigenic Target-6–Free Interferon-gamma Release Assay Compared to QuantiFERON-TB Gold In-tube | Zendy

Elisa Nemes | Zendy; Deborah Abrahams | Zendy; Thomas J. Scriba | Zendy; Frances Ratangee | Zendy; Alana Keyser | Zendy; Lebohang Makhethe | Zendy; Mzwandile Erasmus | Zendy; Simbarashe Mabwe | Zendy; Nicole Bilek | Zendy; Virginie Rozot | Zendy; Hennie Geldenhuys | Zendy; Mark Hatherill | Zendy; Maria Lempicki | Zendy; Line Lindebo Holm | Zendy; Leah Bogardus | Zendy; Ann M. Ginsberg | Zendy; Thomas Blauenfeldt | Zendy; Bronwyn Smith | Zendy; Ruth D. Ellis | Zendy; André G. Loxton | Zendy; Gerhard Walzl | Zendy; Peter Andersen | Zendy; Morten Rühwald | Zendy

Open Access

Diagnostic Accuracy of Early Secretory Antigenic Target-6–Free Interferon-gamma Release Assay Compared to QuantiFERON-TB Gold In-tube

Author(s) -

Elisa Nemes,

Deborah Abrahams,

Thomas J. Scriba,

Frances Ratangee,

Alana Keyser,

Lebohang Makhethe,

Mzwandile Erasmus,

Simbarashe Mabwe,

Nicole Bilek,

Virginie Rozot,

Hennie Geldenhuys,

Mark Hatherill,

Maria Lempicki,

Line Lindebo Holm,

Leah Bogardus,

Ann M. Ginsberg,

Thomas Blauenfeldt,

Bronwyn Smith,

Ruth D. Ellis,

André G. Loxton,

Gerhard Walzl,

Peter Andersen,

Morten Rühwald

Publication year - 2019

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciz034

Subject(s) - medicine , quantiferon , tuberculosis , mcnemar's test , antigen , immunology , mycobacterium tuberculosis , tuberculosis diagnosis , interferon gamma release assay , esat 6 , confidence interval , gold standard (test) , tuberculin , virology , latent tuberculosis , pathology , statistics , mathematics

Early secretory antigenic target-6 (ESAT-6) is an immunodominant Mycobacterium tuberculosis (M.tb) antigen included in novel vaccines against tuberculosis (TB) and in interferon-gamma (IFN-γ) release assays (IGRAs). Therefore, the availability of an ESAT-6-free IGRA is essential to determine M.tb infection status following vaccination with ESAT-6-containing vaccines. We aimed to qualify a recently developed ESAT-6-free IGRA and to assess its diagnostic performance in comparison to QuantiFERON-TB Gold In-tube (QFT).

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