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Pulmonary Metagenomic Sequencing Suggests Missed Infections in Immunocompromised Children
Author(s) -
Matt S. Zinter,
Christopher C. Dvorak,
Madeline Y. Mayday,
Kensho Iwanaga,
Ngoc P. Ly,
Meghan E. McGarry,
Gwynne Church,
Lauren Elizabeth Faricy,
Courtney M. Rowan,
Janet R. Hume,
Marie E. Steiner,
Emily Crawford,
Charles Langelier,
Katrina Kalantar,
Eric D. Chow,
Steve Miller,
Kristen Shimano,
Alexis Melton,
Gregory A. Yanik,
Anil Sapru,
Joseph L. DeRisi
Publication year - 2018
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/ciy802
Subject(s) - medicine , metagenomics , intensive care medicine , medline , immunology , genetics , gene , biology , biochemistry
Despite improved diagnostics, pulmonary pathogens in immunocompromised children frequently evade detection, leading to significant mortality. Therefore, we aimed to develop a highly sensitive metagenomic next-generation sequencing (mNGS) assay capable of evaluating the pulmonary microbiome and identifying diverse pathogens in the lungs of immunocompromised children.

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