Chloroquine Versus Dihydroartemisinin-Piperaquine With Standard High-dose Primaquine Given Either for 7 Days or 14 Days in Plasmodium vivax Malaria | Zendy

Cindy S. Chu | Zendy; Aung Pyae Phyo | Zendy; Claudia Turner | Zendy; Htun Htun Win | Zendy; Naw Pet Poe | Zendy; Widi Yotyingaphiram | Zendy; Suradet Thinraow | Zendy; Pornpimon Wilairisak | Zendy; Rattanaporn Raksapraidee | Zendy; Verena I. Carrara | Zendy; Moo Kho Paw | Zendy; Jacher Wiladphaingern | Zendy; Stéphane Proux | Zendy; Germana Bancone | Zendy; Kanlaya Sriprawat | Zendy; Sue J. Lee | Zendy; Atthanee Jeeyapant | Zendy; James A Watson | Zendy; Joel Tärning | Zendy; Mallika Imwong | Zendy; François Nosten | Zendy; Nicholas J. White | Zendy

Open Access

Chloroquine Versus Dihydroartemisinin-Piperaquine With Standard High-dose Primaquine Given Either for 7 Days or 14 Days in Plasmodium vivax Malaria

Author(s) -

Cindy S. Chu,

Aung Pyae Phyo,

Claudia Turner,

Htun Htun Win,

Naw Pet Poe,

Widi Yotyingaphiram,

Suradet Thinraow,

Pornpimon Wilairisak,

Rattanaporn Raksapraidee,

Verena I. Carrara,

Moo Kho Paw,

Jacher Wiladphaingern,

Stéphane Proux,

Germana Bancone,

Kanlaya Sriprawat,

Sue J. Lee,

Atthanee Jeeyapant,

James A Watson,

Joel Tärning,

Mallika Imwong,

François Nosten,

Nicholas J. White

Publication year - 2018

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciy735

Subject(s) - primaquine , piperaquine , plasmodium vivax , dihydroartemisinin , malaria , chloroquine , vivax malaria , medicine , pharmacology , artemisinin , immunology , plasmodium falciparum

Primaquine is necessary for the radical cure of Plasmodium vivax malaria, but the optimum duration of treatment and best partner drug are uncertain. A randomized controlled trial was performed to compare the tolerability and radical curative efficacy of 7-day versus 14-day high-dose primaquine regimens (total dose 7mg/kg) with either chloroquine or dihydroartemisinin-piperaquine.

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