Repurposing an Old Drug for a New Epidemic: Ursodeoxycholic Acid to Prevent RecurrentClostridioides difficileInfection | Zendy

Brandon Webb | Zendy; Ali Brunner | Zendy; Julia B. Lewis | Zendy; Clyde D. Ford | Zendy; Bert K. Lopansri | Zendy

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Repurposing an Old Drug for a New Epidemic: Ursodeoxycholic Acid to Prevent RecurrentClostridioides difficileInfection

Author(s) -

Brandon Webb,

Ali Brunner,

Julia B. Lewis,

Clyde D. Ford,

Bert K. Lopansri

Publication year - 2018

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciy568

Subject(s) - ursodeoxycholic acid , clostridioides , medicine , repurposing , drug , drug repositioning , gastroenterology , pharmacology , ecology , biology

Recurrent Clostridioides difficile infection (rCDI) may be mediated in part by secondary bile acids. Here we report salvage therapy with ursodeoxycholic acid (UDCA) to prevent rCDI in 16 high-risk patients. Patients on UDCA had a low observed recurrence rate (12.5%). Controlled trials are needed to confirm these observations.

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