Rapid Rebound of a Preexisting CXCR4-tropic Human Immunodeficiency Virus Variant After Allogeneic Transplantation With CCR5 Δ32 Homozygous Stem Cells | Zendy

Jens Verheyen | Zendy; Alexander Thielen | Zendy; Nadine Lübke | Zendy; Miriam Dirks | Zendy; Marek Widera | Zendy; Ulf Dittmer | Zendy; Lambros Kordelas | Zendy; Martin Däumer | Zendy; Dorien C. M. de Jong | Zendy; Annemarie M. J. Wensing | Zendy; Rolf Kaiser | Zendy; Monique Nijhuis | Zendy; Stefan Eßer | Zendy

Open Access

Rapid Rebound of a Preexisting CXCR4-tropic Human Immunodeficiency Virus Variant After Allogeneic Transplantation With CCR5 Δ32 Homozygous Stem Cells

Author(s) -

Jens Verheyen,

Alexander Thielen,

Nadine Lübke,

Miriam Dirks,

Marek Widera,

Ulf Dittmer,

Lambros Kordelas,

Martin Däumer,

Dorien C. M. de Jong,

Annemarie M. J. Wensing,

Rolf Kaiser,

Monique Nijhuis,

Stefan Eßer

Publication year - 2018

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciy565

Subject(s) - transplantation , cxcr4 , stem cell , medicine , virology , human immunodeficiency virus (hiv) , virus , immunology , viral disease , lentivirus , hematopoietic stem cell transplantation , immunodeficiency , severe combined immunodeficiency , biology , genetics , gene , chemokine , inflammation , immune system

Allogeneic stem cell transplantation (alloSCT) of homozygous CCR5 Δ32 stem cells once resulted in the cure of human immunodeficiency virus (HIV) infection. We have recently reported a viral breakthrough in a similar setting. Here, we demonstrate that the rapid rebound after alloSCT was related to a highly replicative CXCR4-tropic HIV variant, which could already be detected before alloSCT.

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