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We describe the rapid and ongoing emergence across multiple US cities of a new multidrug-resistant Escherichia coli clone-sequence type (ST) 1193-resistant to fluoroquinolones (100%), trimethoprim-sulfamethoxazole (55%), and tetracycline (53%). ST1193 is associated with younger adults (age &lt;40 years) and currently comprises a quarter of fluoroquinolone-resistant clinical E. coli urine isolates.

Rapid and Extensive Expansion in the United States of a New Multidrug-resistantEscherichia coliClonal Group, Sequence Type 1193