Short-course High-dose Liposomal Amphotericin B for Human Immunodeficiency Virus–associated Cryptococcal Meningitis: A Phase 2 Randomized Controlled Trial | Zendy

Joseph N Jarvis | Zendy; Tshepo Leeme | Zendy; Mooketsi Molefi | Zendy; Awilly A Chofle | Zendy; Gabriella Bidwell | Zendy; Katlego Tsholo | Zendy; Nametso Tlhako | Zendy; Norah Mawoko | Zendy; Raju K K Patel | Zendy; Mark W. Tenforde | Zendy; Charles Muthoga | Zendy; Gregory P. Bisson | Zendy; Kidola Jeremiah | Zendy; John Changalucha | Zendy; David S. Lawrence | Zendy; Shabbar Jaffar | Zendy; William Hope | Zendy; Síle F. Molloy | Zendy; Thomas S. Harrison | Zendy

Open Access

Short-course High-dose Liposomal Amphotericin B for Human Immunodeficiency Virus–associated Cryptococcal Meningitis: A Phase 2 Randomized Controlled Trial

Author(s) -

Joseph N Jarvis,

Tshepo Leeme,

Mooketsi Molefi,

Awilly A Chofle,

Gabriella Bidwell,

Katlego Tsholo,

Nametso Tlhako,

Norah Mawoko,

Raju K K Patel,

Mark W. Tenforde,

Charles Muthoga,

Gregory P. Bisson,

Kidola Jeremiah,

John Changalucha,

David S. Lawrence,

Shabbar Jaffar,

William Hope,

Síle F. Molloy,

Thomas S. Harrison

Publication year - 2018

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciy515

Subject(s) - medicine , amphotericin b , confidence interval , cryptococcal meningitis , clinical endpoint , randomized controlled trial , fluconazole , meningitis , dose , human immunodeficiency virus (hiv) , gastroenterology , surgery , immunology , antifungal , viral disease , dermatology

We performed a phase 2 noninferiority trial examining the early fungicidal activity (EFA) of 3 short-course, high-dose liposomal amphotericin B (L-AmB) regimens for cryptococcal meningitis (CM) in Tanzania and Botswana.

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